2023
1. “Development of 1,3,6-Tribenzoylated Glucose as an Antiausterity Agent Targeting Tumor Microenvironment” Akira Takagi, Kazuki Usuguchi, Ippei Takashima, and Kensuke Okuda; Chem. Pharm. Bull. 71(8), 641–649 (2023).
2. “Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems” Kensuke Okuda, Ippei Takashima, and Akira Takagi; J. Clin. Biochem. Nutr. 72(1), 1–12 (2023).
2022
1. “BOOKS紹介 THE創薬 ー少資源国家”にっぽん”の生きる道ー” 北西悟司; MEDCHEM NEWS 32(3), 131 (2022).
2. “Catalytic Intramolecular Cyclization of Alkynyl Cyclic Acetals via Chemoselective Activation Leading to Phenanthrene Core” Tsuyoshi Yamada, Akiko Fujii, Kwihwan Park, Chikara Furugen, Akira Takagi, Takashi Ikawa, Hironao Sajiki; Bull. Chem. Soc. Jpn. 95(5), 735–742 (2022).
3. “Extracts of Musa basjoo induce growth inhibition and changes in the protein expression of cell cycle control molecules in human colorectal cancer cell lines” Harutoshi Matsumoto Saeko Ando Eri Yoshimoto Takamasa Numano Nahida Sultana Katsumi Fukamachi Munekazu Iinuma Kensuke Okuda Kazunori Kimura and Masumi Suzui; Oncol. Lett. 23(3), 99 (2022).
2021
1. “亜鉛触媒反応を応用した細胞内亜鉛イオンの高感度検出プローブの開発” 高嶋一平，高木晃，奥田健介; 亜鉛栄養治療 12(1), 15–23 (2021).
2. “Could London Dispersion Force Control Regioselective (2 + 2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes” Takashi Ikawa, Yuta Yamamoto, Akito Heguri, Yutaka Fukumoto, Tomonari Murakami, Akira Takagi, Yuto Masuda, Kenzo Yahata, Hiroshi Aoyama, Yasuteru Shigeta, Hiroaki Tokiwa, and Shuji Akai; J. Am. Chem. Soc. 143(29), 10853–10859 (2021).
3. “Total Synthesis of Antiausterity Agent (±)-Uvaridacol L by Regioselective Axial Diacylation of a myo-Inositol Orthoester” Akira Takagi, Kazuki Usuguchi, Ippei Takashima, and Kensuke Okuda; Org. Lett. 23(11), 4083–4087 (2021).
↑こちらの論文がSynfacts誌で紹介されました（”Synthesis of (±)-Uvaridacol L: An Antiausterity Agent” Synfacts 17(5), 0578 (2021)）。
4. “Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment” Takayuki Sakai, Yoshiyuki Matsuo, Kensuke Okuda, Kiichi Hirota, Mieko Tsuji, Tasuku Hirayama, and Hideko Nagasawa; Sci. Rep. 11, 4852 (2021).
2020
1. “A fluorogenic probe using a catalytic reaction for the detection of trace intracellular zinc” Ippei Takashima, Yohei Inoue, Nobuyuki Matsumoto, Akira Takagi, and Kensuke Okuda; Chem. Commun. 56(87), 13327–13330 (2020).
2. “One-Pot Generation of Functionalized Benzynes from Readily Available 2‑Hydroxyphenylboronic Acids” Takashi Ikawa, JingKai Sun, Akira Takagi, and Shuji Akai; J. Org. Chem. 85(5), 3383–3392 (2020).
3. “Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation” Norika Goto, Hirokazu Hara, Mao Kondo, Naomi Yasuda, Tetsuro Kamiya, Kensuke Okuda, and Tetsuo Adachi; Metallomics, 12(6), 868–875 (2020).
4. “Development of Near-Infrared Fluorescent Probes with Large Stokes Shift for Non-Invasive Imaging of Tumor Hypoxia” Kensuke Okuda, Bahaa G. M. Youssif, Ryosuke Sakai, Takahiro Ueno, Takayuki Sakai, Tetsuya Kadonosono, Yasuyuki Okabe, Ola I. Abdel Razek Salem, Alaa M. Hayallah, Mostafa A. Hussein, Shinae Kizaka-Kondoh, and Hideko Nagasawa; Heterocycles 101(2), 559–579 (2020).
2019
1. “Effects of 2-(2-Chlorophenyl)ethylbiguanide on ERAD Component Expression in HT-29 Cells Under a Serum- and Glucose-Deprived Condition” Kentaro Oh-hashi, Shiori Matsumoto, Takayuki Sakai, Yoko Hirata, Kensuke Okuda and Hideko Nagasawa, Appl. Biochem. Biotechnol. 188(4) 1009–1021 (2019).
2.“Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity” Hirofumi Tsujino, Tadayuki Uno, Taku Yamashita, Masafumi Katsuda, Kazuki Takada, Takeshi Saiki, Shotaro Maeda, Akira Takagi, Shigeaki Masuda, Yasuhiko Kawano, Kanji Meguro, and Shuji Akai; Bioorg. Med. Chem. Lett. 29(19), 126607 (2019).
2018
1. “Elucidating the rapid action of 2-(2-chlorophenyl)ethylbiguanide on HT-29 cells under a serum- and glucose-deprived condition” Kentaro Oh-hashi, Shiori Matsumoto, Takayuki Sakai, Yuki Nomura, Kensuke Okuda, Hideko Nagasawa, and Yoko Hirata; Cell Biol. Toxicol. 34(4), 279–290 (2018).
2. “Synthesis of Optically Active 2,3-Disubstituted Indoline Derivatives via Cycloaddition Reactions between Benzynes and α,β-Unsaturated-γ-aminobutyronitriles“ Takashi Ikawa, Yuta Sumii, Shigeaki Masuda, Ding Wang, Yuto Emi, Akira Takagi, and Shuji Akai; Synlett 29(4), 530–536 (2018).
3. “ベンザインの効率的発生法” 高木晃; YAKUGAKU ZASSHI 138(1), 27–35 (2018).
2017
1. “A universal fluorogenic switch for Fe(II) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells” Tasuku Hirayama, Hitomi Tsuboi, Masato Niwa, Satoki Kadota, Ayaji Miki, Kensuke Okuda, and Hideko Nagasawa; Chem. Sci. 8(7), 4858–4866 (2017).
2. “Bismuth-rhodamine: a new red light-excitable photosensitizer” Tasuku Hirayama, Akari Mukaimine, Kenta Nishigaki, Hitomi Tsuboi, Shusaku Hirosawa, Kensuke Okuda, Masahiro Ebihara, and Hideko Nagasawa; Dalton Trans. 46(46), 15991–15995 (2017).
3. “Hydrogen sulfide ameliorates zinc-induced cell death in neuroblastoma SH-SY5Y cells” Megumi Shimoji, Hirokazu Hara, Tetsuro Kamiya, Kensuke Okuda, and Tetsuo Adachi; Free Radical Res. 51(11–12), 978–985 (2017).
4. “Frustrated Lewis Pairs (FLPs)を用いたメタルフリーC-Hボリル化反応” 高木晃; 有機合成化学協会誌 Review de Debut 75, 362–363 (2017).
5. “N-ヘテロ環状カルベン触媒の新たな利用法：イミンの極性転換” 高木晃; ファルマシア 53, 1016 (2017).
2016
1. “In vivo Retinal and Choroidal Hypoxia Imaging Using a Novel Activatable Hypoxia-Selective Near-Infrared Fluorescent Probe” Shinichi Fukuda, Kensuke Okuda, Genichiro Kishino, Sujin Hoshi, Itsuki Kawano, Masahiro Fukuda, Toshiharu Yamashita, Simone Beheregaray, Masumi Nagano, Osamu Ohneda, Hideko Nagasawa, and Tetsuro Oshika; Graefes Arch. Clin. Exp. Ophthalmol. 254(12), 2373–2385 (2016).
2. “Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells” Kentaro Oh-hashi, Nao Irie, Takayuki Sakai, Kensuke Okuda, Hideko Nagasawa, Yoko Hirata, and Kazutosi Kiuchi; Mol. Cell Biochem. 419(1), 29–40 (2016).
3. “Solution-Phase Synthesis and Biological Evaluation of Triostin A and its Analogues” Kozo Hattori, Kota Koike, Kensuke Okuda, Tasuku Hirayama, Masahiro Ebihara, Mei Takenaka, and Hideko Nagasawa; Org. Biomol. Chem. 14(6), 2090–2111 (2016).
4. “1,3- and 1,4-Benzdiyne equivalents for regioselective synthesis of polycyclic heterocycles” Takashi Ikawa, Shigeaki Masuda, Akira Takagi, Shuji Akai; Chem. Sci. 7(8), 5206–5211 (2016).
2015年以前の論文業績はこちら